Cell and gene therapies (CGTs) offer an unprecedented opportunity to treat diseases for which existing interventions are inadequate, potentially offering cures for previously terminal illnesses. However, several challenges have arisen for CGT developers and manufacturing partners due to the complex and time consuming processes involved. One of the primary manufacturing challenges currently bottlenecking the industry is the increasing demand for viral vectors.
Evolution analysed all 209 active interventional FDA clinical trials involving cell and gene therapies. For each clinical trial, we outlined whether the therapy was allogeneic or autologous, and identified the vectors used. For autologous therapies undergoing clinical trials, we also examined the cell lines used.
Our analysis provides a holistic view of the rapidly evolving cell and gene therapy industry, offering bioproduction companies and contract development and manufacturing organisations an insight into the future requirements of their customers.